Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13159948 | 0.76 | KDM4E (0.46) | POLBCYP1A2GAAKDM4EGRM5 | |
| SCHEMBL20866435 | 0.75 | SSTR4 (0.33) | POLBCYP1A2GAAKDM4EGRM5 | |
| SCHEMBL20939482 | 0.74 | POLB (0.34) | POLBCYP1A2GAAKDM4EGRM5 | |
| SCHEMBL20631145 | 0.74 | LMNA (0.30) | KDM4ELMNA | |
| SCHEMBL14737830 | 0.74 | POLB (0.34) | POLBCYP1A2GAAKDM4EGRM5 | |
| SCHEMBL15730331 | 0.74 | LMNA (0.51) | POLBCYP1A2GAAHTTLMNA | |
| SCHEMBL14752475 | 0.71 | PARP1 (0.43) | POLBCYP1A2GAAKDM4EGRM5 | |
| SCHEMBL17051109 | 0.71 | POLB (0.36) | POLBCYP1A2GAAKDM4EGRM5 | |
| SCHEMBL14751267 | 0.71 | BRD4 (0.41) | POLBCYP1A2GAAKDM4EGRM5 | |
| SCHEMBL14738222 | 0.70 | POLB (0.38) | POLBCYP1A2GAAKDM4EGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |