Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.34 |
| ▸ | CDK2 | P24941 | 4/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21958655 | 0.98 | GRM5 (0.40) | GRM5TSHRBRD4CREBBPCNR2 | |
| SCHEMBL20674215 | 0.82 | GRM5 (0.55) | GRM5TSHRBRD4CREBBPCNR2 | |
| SCHEMBL20631137 | 0.81 | GRIA2 (0.38) | GRM5TSHRMEN1KMT2AMAPT | |
| SCHEMBL20631144 | 0.79 | KMT2A (0.42) | GRM5TSHRCNR2MEN1KMT2A | |
| SCHEMBL23937925 | 0.78 | HDAC10 (0.31) | — | |
| SCHEMBL20631122 | 0.77 | LMNA (0.39) | GRM5TSHRCNR2MEN1KMT2A | |
| SCHEMBL20631123 | 0.75 | LMNA (0.35) | GRM5TSHRCNR2MAPTALDH1A1 | |
| SCHEMBL21958681 | 0.74 | LMNA (0.36) | GRM5MEN1KMT2AMAPTKDM4E | |
| SCHEMBL20631125 | 0.72 | GAA (0.39) | MEN1KMT2AGAAPOLBCYP1A2 | |
| SCHEMBL20673851 | 0.70 | TSHR (0.39) | TSHRBRD4CREBBPMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |