Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 5/20 | 0.41 |
| ▸ | LCK | P06239 | 5/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.41 |
| ▸ | MET | P08581 | 4/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | CLK2 | P49760 | 4/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.41 |
| ▸ | CSF1R | P07333 | 4/20 | 0.41 |
| ▸ | GSK3A | P49840 | 3/20 | 0.41 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 3/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.41 |
| ▸ | RET | P07949 | 3/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL422306 | 0.79 | MRGPRX1 (0.47) | MAP4K4LCKMAP4K2METKDR | |
| SCHEMBL23599237 | 0.76 | MAP4K4 (0.50) | MAP4K4LCKMAP4K2METKDR | |
| SCHEMBL23599233 | 0.76 | MRGPRX1 (0.45) | MAP4K4LCKMAP4K2METKDR | |
| SCHEMBL1901292 | 0.72 | MAP4K4 (0.53) | MAP4K4LCKMAP4K2METKDR | |
| SCHEMBL13747077 | 0.72 | SMN1; SMN2 (0.41) | MAP4K4LCKMAP4K2METKDR | |
| SCHEMBL16801668 | 0.69 | FGFR1 (0.67) | MAP4K4LCKMAP4K2METKDR | |
| SCHEMBL13763179 | 0.68 | CYP17A1 (0.40) | MAP4K4LCKMAP4K2METKDR | |
| SCHEMBL16281238 | 0.67 | KDM4E (0.56) | L3MBTL1ALDH1A1LMNAKDM4ETSHR | |
| SCHEMBL13527777 | 0.67 | SMN1; SMN2 (0.68) | FGFR1L3MBTL1ALDH1A1LMNAKDM4E | |
| SCHEMBL15743285 | 0.65 | MAP4K4 (0.50) | MAP4K4LCKMAP4K2METKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210323975-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | VALO EARLY DISCOVERY, INC. | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210323975-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | USP28, USP25, USP24 | MAP4K4 1430/4885LCK 3439/4885MAP4K2 1173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.