⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20732079 | 0.76 | — | — | |
| SCHEMBL14311987 | 0.73 | — | — | |
| SCHEMBL23938257 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL14311821 | 0.71 | DRD4 (0.34) | — | |
| SCHEMBL22962311 | 0.68 | CYP2D6 (0.35) | — | |
| SCHEMBL23754166 | 0.68 | OPRM1 (0.33) | — | |
| SCHEMBL22962292 | 0.68 | CYP2D6 (0.35) | — | |
| SCHEMBL22962266 | 0.68 | CYP2D6 (0.35) | — | |
| SCHEMBL26926194 | 0.68 | OPRM1 (0.33) | — | |
| SCHEMBL28209946 | 0.67 | KDM4E (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11524966-B1 | Carboxamides as ubiquitin-specific protease inhibitors | VALO HEALTH, INC. (US) | 2022-12-13 | — | — | US | disclosed |
| US-20210323975-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | VALO EARLY DISCOVERY, INC. | 2021-10-21 | — | — | US | disclosed |