Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 15/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.59 |
| ▸ | TACR1 | P25103 | 4/20 | 0.53 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18253090 | 1.00 | CCR2 (0.59) | CCR2KCNH2TACR1OPRL1 | |
| SCHEMBL18252940 | 0.94 | CCR2 (0.66) | CCR2KCNH2TACR1 | |
| SCHEMBL24433874 | 0.94 | CCR2 (0.66) | CCR2KCNH2TACR1 | |
| SCHEMBL18253110 | 0.90 | CCR2 (0.55) | CCR2KCNH2TACR1OPRL1 | |
| SCHEMBL19443087 | 0.89 | CCR2 (0.55) | CCR2KCNH2TACR1OPRL1 | |
| SCHEMBL23938462 | 0.89 | CCR2 (0.55) | CCR2KCNH2TACR1OPRL1 | |
| SCHEMBL21900433 | 0.89 | CCR2 (0.55) | CCR2KCNH2TACR1OPRL1 | |
| SCHEMBL18253111 | 0.89 | CCR2 (0.55) | CCR2KCNH2TACR1OPRL1 | |
| SCHEMBL18253085 | 0.89 | CCR2 (0.75) | CCR2KCNH2TACR1 | |
| SCHEMBL18253078 | 0.88 | CCR2 (0.53) | CCR2KCNH2TACR1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3297438-B1 | CCR2 MODULATORS | CHEMOCENTRYX INC (US) | 2021-10-20 | — | — | EP | disclosed |