Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.37 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23096263 | 0.81 | KDR (0.33) | KDREGFRKDM4EALDH1A1MAPK1 | |
| SCHEMBL24392406 | 0.79 | KDR (0.37) | KDREGFRMAPK14 | |
| SCHEMBL24393356 | 0.79 | KDR (0.38) | KDREGFRMAPK14 | |
| SCHEMBL23939422 | 0.79 | EGFR (0.35) | KDREGFRKDM4EALDH1A1MAPK1 | |
| SCHEMBL23096261 | 0.76 | ALDH1A1 (0.33) | KDREGFRALDH1A1 | |
| SCHEMBL24392514 | 0.75 | KDR (0.35) | KDREGFR | |
| SCHEMBL1228109 | 0.70 | MAPT (0.45) | EGFRMAPK14MAPK1 | |
| SCHEMBL4811354 | 0.70 | MAPK14 (0.45) | KDRMAPK14 | |
| SCHEMBL1227597 | 0.69 | MAP2K1 (0.55) | KDREGFRMAPK14 | |
| SCHEMBL12537638 | 0.67 | EGFR (0.52) | KDREGFRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12030897-B2 | Pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and application thereof | MEDSHINE DISCOVERY INC. (CN) | 2024-07-09 | — | — | US | disclosed |
| US-12030897-B2 | Pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and application thereof | MEDSHINE DISCOVERY INC. (CN) | 2024-07-09 | — | — | US | disclosed |
| US-20210323979-A1 | PYRROLO[2,1-F][1,2,4]TRIAZINE DERIVATIVES SERVING AS SELECTIVE HER2 INHIBITORS AND APPLICATION THEREOF | MEDSHINE DISCOVERY INC. (CN) | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12030897-B2 | Pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and application thereof | ERBB2, EGFR, ERBB3 | KDR 78/4885EGFR 2/4885MAPK14 469/4885 |
| US-20210323979-A1 | PYRROLO[2,1-F][1,2,4]TRIAZINE DERIVATIVES SERVING AS SELECTIVE HER2 INHIBITORS AND APPLICATION THEREOF | ERBB2, EGFR, ERBB3 | KDR 78/4885EGFR 2/4885MAPK14 469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.