Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 17/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.51 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.51 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.51 |
| ▸ | MAT2A | P31153 | 1/20 | 0.44 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2394051 | 0.84 | TGFBR1 (0.72) | ABCG2PRKD3TGFBR1PRKD1PRKD2 | |
| SCHEMBL5555419 | 0.81 | TGFBR1 (0.53) | ABCG2PRKD3TGFBR1PRKD1PRKD2 | |
| SCHEMBL12261412 | 0.81 | PRKD3 (0.56) | ABCG2PRKD3TGFBR1PRKD1PRKD2 | |
| SCHEMBL5551427 | 0.79 | PRKD3 (0.48) | ABCG2PRKD3TGFBR1PRKD1PRKD2 | |
| SCHEMBL2396089 | 0.79 | TGFBR1 (0.51) | ABCG2PRKD3TGFBR1PRKD1PRKD2 | |
| SCHEMBL5551847 | 0.79 | TGFBR1 (0.51) | ABCG2PRKD3TGFBR1PRKD1PRKD2 | |
| SCHEMBL2210408 | 0.76 | TGFBR1 (0.53) | ABCG2PRKD3TGFBR1PRKD1PRKD2 | |
| SCHEMBL2491506 | 0.75 | TGFBR1 (0.54) | ABCG2PRKD3TGFBR1PRKD1PRKD2 | |
| SCHEMBL14344386 | 0.74 | PRKD3 (0.58) | ABCG2PRKD3TGFBR1PRKD1PRKD2 | |
| SCHEMBL14564461 | 0.74 | TGFBR1 (0.56) | ABCG2PRKD3TGFBR1PRKD1PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022077-B2 | Pyrido[2,3-d]pyrimidines useful as HCV inhibitors, and methods for the preparation thereof | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2011-09-20 | — | — | US | disclosed |
| EP-1888580-B1 | PYRIDO[2,3-D]PYRIMIDINES USEFUL AS HCV INHIBITORS, AND METHODS FOR THE PREPARATION THEREOF | TIBOTEC PHARM LTD (IE) | 2010-03-03 | — | — | EP | disclosed |
| EP-1888580-A2 | PYRIDO[2,3-D]PYRIMIDINES USEFUL AS HCV INHIBITORS, AND METHODS FOR THE PREPARATION THEREOF | Tibotec Pharmaceuticals Ltd. (IE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006120252-A2 | PYRIDO[2,3-D]PYRIMIDINES USEFUL AS HCV INHIBITORS, AND METHODS FOR THE PREPARATION THEREOF | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2006-11-16 | — | — | WO | disclosed |