Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 20/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1558859 | 0.91 | DGAT1 (0.45) | LRRK2 | |
| SCHEMBL1558586 | 0.87 | LRRK2 (0.49) | LRRK2 | |
| SCHEMBL1558253 | 0.87 | LRRK2 (0.46) | LRRK2 | |
| SCHEMBL1558837 | 0.87 | LRRK2 (0.43) | LRRK2 | |
| SCHEMBL1557449 | 0.87 | LRRK2 (0.42) | LRRK2 | |
| SCHEMBL2400727 | 0.86 | LRRK2 (0.48) | LRRK2 | |
| SCHEMBL2395588 | 0.83 | ACVR1 (0.44) | LRRK2 | |
| SCHEMBL1557499 | 0.82 | MKNK1 (0.44) | LRRK2 | |
| SCHEMBL1558639 | 0.82 | SRC (0.41) | LRRK2 | |
| SCHEMBL2399164 | 0.81 | MTOR (0.43) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212053-A1 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PROGENICS PHARMACEUTICALS, INC. | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212053-A1 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PIK3CA, AKT1, PIK3R5 | LRRK2 372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.