Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.30 |
| ▸ | USP2 | O75604 | 2/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HRH2 | P25021 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23807071 | 0.96 | S1PR1 (0.32) | CA1CYP2D6S1PR1S1PR3S1PR5 | |
| SCHEMBL25887824 | 0.93 | S1PR1 (0.33) | CYP2D6S1PR1S1PR3S1PR5TSHR | |
| SCHEMBL24673701 | 0.92 | S1PR1 (0.32) | CA1CYP2D6S1PR1S1PR3S1PR5 | |
| SCHEMBL25927044 | 0.90 | S1PR4 (0.31) | CA1CYP2D6S1PR1S1PR3S1PR5 | |
| SCHEMBL25829042 | 0.86 | CYP2D6 (0.33) | CYP2D6TSHRCYP1A2HIF1AUSP2 | |
| SCHEMBL24672551 | 0.85 | LMNA (0.38) | S1PR1S1PR3S1PR5TSHRS1PR4 | |
| SCHEMBL25923473 | 0.84 | CYP2D6 (0.32) | CYP2D6TSHRCYP1A2HIF1AUSP2 | |
| SCHEMBL23806954 | 0.84 | CYP2D6 (0.34) | CYP2D6TSHRCYP1A2HIF1AUSP2 | |
| SCHEMBL25829588 | 0.84 | ACE2 (0.41) | CA1CYP2D6S1PR1S1PR3S1PR5 | |
| SCHEMBL23696753 | 0.83 | ACE2 (0.40) | CA1CYP2D6S1PR1S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352350-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2022-06-07 | — | — | US | disclosed |
| US-20210323952-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352350-B2 | IRAK degraders and uses thereof | IRAK2, IRAK3, IRAK1 | CA1 4622/4885CYP2D6 3599/4885S1PR1 2230/4885 |
| US-20210323952-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | CA1 4622/4885CYP2D6 3599/4885S1PR1 2230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.