⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL840007 | 0.89 | GRIA1 (0.32) | — | |
| SCHEMBL3690414 | 0.82 | ALDH1A1 (0.36) | — | |
| SCHEMBL20812165 | 0.82 | HRH4 (0.37) | — | |
| SCHEMBL13884361 | 0.82 | HRH4 (0.37) | — | |
| SCHEMBL13884349 | 0.82 | HRH4 (0.37) | — | |
| SCHEMBL10226405 | 0.82 | HRH4 (0.37) | — | |
| SCHEMBL14509576 | 0.82 | HRH4 (0.37) | — | |
| SCHEMBL20812158 | 0.82 | HRH4 (0.37) | — | |
| SCHEMBL4744735 | 0.82 | HRH4 (0.37) | — | |
| SCHEMBL21654853 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230144292-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-05-11 | — | — | US | disclosed |
| US-11352350-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2022-06-07 | — | — | US | disclosed |
| US-20210323952-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2021-10-21 | — | — | US | disclosed |