Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 7/20 | 0.69 |
| ▸ | AKT1 | P31749 | 3/20 | 0.57 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19686108 | 1.00 | SCN4A (0.69) | SCN4AAKT1CHRNB2CHRNA4CFTR | |
| SCHEMBL4345367 | 0.82 | SCN4A (1.00) | SCN4A | |
| SCHEMBL12847267 | 0.82 | SCN4A (1.00) | SCN4A | |
| SCHEMBL19686196 | 0.81 | SCN4A (0.76) | SCN4AAKT1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19686206 | 0.79 | SCN4A (0.62) | SCN4AAKT1 | |
| SCHEMBL19686194 | 0.77 | SCN4A (0.58) | SCN4AAKT1 | |
| SCHEMBL23406075 | 0.76 | SCN4A (0.57) | SCN4AAKT1 | |
| SCHEMBL29743841 | 0.76 | SCN4A (0.57) | SCN4AAKT1 | |
| SCHEMBL23406078 | 0.76 | SCN4A (0.57) | SCN4AAKT1 | |
| SCHEMBL27674373 | 0.75 | CHRNB2 (0.50) | AKT1CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012901-B1 | Method of synthesizing enantiopure mexiletine analogues and novel β-thiophenoxy and pyridyl ethers | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-09-06 | — | — | US | disclosed |
| US-8012901-B1 | Method of synthesizing enantiopure mexiletine analogues and novel β-thiophenoxy and pyridyl ethers | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-09-06 | — | — | US | disclosed |
| US-8012901-B1 | Method of synthesizing enantiopure mexiletine analogues and novel β-thiophenoxy and pyridyl ethers | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-09-06 | — | — | US | disclosed |