SCHEMBL23947626

SCHEMBL23947626

COc1cc(N)ncc1N1CCN(C(=O)c2ccc(Oc3ccccc3)cn2)CC1

nearest known ligand 0.81

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TRPC6 Q9Y210 20/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30387320 0.89 TRPC6 (1.00) TRPC6
SCHEMBL21045847 0.89 TRPC6 (1.00) TRPC6
SCHEMBL21045804 0.83 TRPC6 (1.00) TRPC6
SCHEMBL21045765 0.83 TRPC6 (1.00) TRPC6
SCHEMBL30387614 0.83 TRPC6 (1.00) TRPC6
SCHEMBL23047371 0.83 TRPC6 (1.00) TRPC6
SCHEMBL21045768 0.83 TRPC6 (1.00) TRPC6
SCHEMBL30387453 0.83 TRPC6 (1.00) TRPC6
SCHEMBL21274207 0.82 TRPC6 (0.74) TRPC6
SCHEMBL29911140 0.82 TRPC6 (0.74) TRPC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021209510-A1 INHIBITORS OF TRPC6 FOR TREATING RESPIRATORY CONDITIONS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2021-10-21 WO disclosed