Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 2/20 | 0.60 |
| ▸ | CCNC | P24863 | 1/20 | 0.60 |
| ▸ | GAK | O14976 | 4/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 4/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.45 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24010748 | 0.86 | FERMT2 (0.60) | CDK8CCNCGAKTGFBR1HTR1A | |
| SCHEMBL2480030 | 0.82 | CDK8 (0.60) | CDK8CCNCGAKRIPK2TGFBR1 | |
| SCHEMBL20935452 | 0.81 | CDK8 (0.56) | CDK8CCNCGAKRIPK2TGFBR1 | |
| SCHEMBL28222299 | 0.81 | CDK8 (0.56) | CDK8CCNCGAKRIPK2TGFBR1 | |
| SCHEMBL25053127 | 0.80 | HTR1A (0.70) | CDK8RIPK2MAPK14HTR1AADRA1D | |
| SCHEMBL22274361 | 0.79 | HTR1A (0.59) | CDK8CCNCGAKHTR1AADRA1D | |
| SCHEMBL2621802 | 0.79 | SLC22A12 (0.69) | CDK8CCNCGAKRIPK2TGFBR1 | |
| SCHEMBL25822655 | 0.77 | CCNC (0.71) | CDK8CCNCGAKTGFBR1MAPKAPK2 | |
| SCHEMBL23999421 | 0.76 | IP6K1 (0.46) | CDK8CCNCHTR1AADRA1DADRA1A | |
| SCHEMBL25520952 | 0.76 | MAPKAPK2 (0.52) | CDK8CCNCHTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021226458-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2021-11-11 | — | — | WO | disclosed |
| WO-2021226519-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2021-11-11 | — | — | WO | disclosed |
| WO-2021226517-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2021-11-11 | — | — | WO | disclosed |
| WO-2021212111-A1 | COMPOSITIONS AND METHODS FOR TREATING LEUKEMIA | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (US) | 2021-10-21 | — | — | WO | disclosed |