Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 7/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | PDE6D | O43924 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | PDE6A | P16499 | 1/20 | 0.31 |
| ▸ | PDE6G | P18545 | 1/20 | 0.31 |
| ▸ | PDE6B | P35913 | 1/20 | 0.31 |
| ▸ | PDE6C | P51160 | 1/20 | 0.31 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.31 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23950209 | 0.86 | NLRP3 (0.43) | NLRP3PDE3APDE4B | |
| SCHEMBL23950372 | 0.82 | NLRP3 (0.42) | NLRP3PDE4B | |
| SCHEMBL23950601 | 0.76 | NLRP3 (0.43) | NLRP3 | |
| SCHEMBL23950598 | 0.74 | NLRP3 (0.63) | NLRP3 | |
| SCHEMBL23952353 | 0.73 | NLRP3 (0.39) | NLRP3PDE3APDE4BKAT2B | |
| SCHEMBL23950371 | 0.73 | PDE4B (0.37) | PDE3APDE4B | |
| SCHEMBL23950365 | 0.72 | KDM4E (0.43) | NLRP3 | |
| SCHEMBL23950432 | 0.71 | NLRP3 (0.38) | NLRP3 | |
| SCHEMBL23950174 | 0.70 | NLRP3 (0.42) | NLRP3PDE6DPDE5APDE6APDE6G | |
| SCHEMBL23950178 | 0.68 | NLRP3 (0.43) | NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021209552-A1 | PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-21 | — | — | WO | disclosed |