Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.39 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | FPR1 | P21462 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.31 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.31 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23950581 | 0.79 | NLRP3 (0.47) | NLRP3ORAI1P2RX3ALDH1A1GPR139 | |
| SCHEMBL23950824 | 0.75 | NLRP3 (0.43) | NLRP3PDE4BPOLB | |
| SCHEMBL25753949 | 0.75 | NLRP3 (0.52) | NLRP3P2RX3THRBGPR139 | |
| SCHEMBL25753938 | 0.74 | NLRP3 (0.51) | NLRP3KMT2ATHRBGPR139 | |
| SCHEMBL25951379 | 0.73 | HTT (0.41) | KMT2APOLBRXFP1ALDH1A1HTT | |
| SCHEMBL25951366 | 0.71 | NLRP3 (0.37) | NLRP3P2RX3POLBRXFP1ALDH1A1 | |
| SCHEMBL23950615 | 0.71 | NLRP3 (0.55) | NLRP3KMT2ATHRBGPR139 | |
| SCHEMBL23950831 | 0.71 | NLRP3 (0.50) | NLRP3THRB | |
| SCHEMBL23950358 | 0.70 | NLRP3 (0.57) | NLRP3ORAI1P2RX3GPR139 | |
| SCHEMBL23950216 | 0.70 | NLRP3 (0.52) | NLRP3ORAI1GPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021209552-A1 | PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-21 | — | — | WO | disclosed |