Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | FPR1 | P21462 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MDM4 | O15151 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23950528 | 0.85 | NLRP3 (0.48) | NLRP3TP53CHRNA7PDE4BTHRB | |
| SCHEMBL25285708 | 0.85 | NLRP3 (0.48) | NLRP3TP53CHRNA7PDE4BTHRB | |
| SCHEMBL23950498 | 0.80 | NLRP3 (0.43) | NLRP3TP53CHRNA7PDE4BPDE3A | |
| SCHEMBL23950606 | 0.80 | NLRP3 (0.42) | NLRP3TP53PDE4BPDE3AKMT2A | |
| SCHEMBL25754628 | 0.72 | NLRP3 (0.50) | NLRP3TP53CHRNA7THRBKMT2A | |
| SCHEMBL23950831 | 0.72 | NLRP3 (0.50) | NLRP3TP53CHRNA7THRB | |
| SCHEMBL25282294 | 0.72 | KMT2A (0.47) | NLRP3TP53CHRNA7THRBKMT2A | |
| SCHEMBL25751776 | 0.72 | KMT2A (0.47) | NLRP3TP53CHRNA7THRBKMT2A | |
| SCHEMBL23950511 | 0.71 | NLRP3 (0.62) | NLRP3TP53THRB | |
| SCHEMBL23950818 | 0.71 | NLRP3 (0.62) | NLRP3TP53THRBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021209552-A1 | PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-21 | — | — | WO | disclosed |