Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 13/20 | 0.53 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23950801 | 0.80 | NLRP3 (0.58) | NLRP3GPR139KCNH2THRB | |
| SCHEMBL23950172 | 0.78 | NLRP3 (0.60) | NLRP3GPR139KCNH2THRB | |
| SCHEMBL23950511 | 0.77 | NLRP3 (0.62) | NLRP3KCNH2THRB | |
| SCHEMBL23950466 | 0.76 | NLRP3 (0.59) | NLRP3GPR139KCNH2 | |
| SCHEMBL25242095 | 0.76 | NLRP3 (0.64) | NLRP3GPR139KCNH2THRB | |
| SCHEMBL30040964 | 0.76 | NLRP3 (0.53) | NLRP3GPR139KCNH2 | |
| SCHEMBL23950385 | 0.75 | NLRP3 (0.61) | NLRP3KCNH2THRB | |
| SCHEMBL25283591 | 0.75 | NLRP3 (0.58) | NLRP3KCNH2THRB | |
| SCHEMBL23950219 | 0.75 | NLRP3 (0.58) | NLRP3KCNH2THRB | |
| SCHEMBL23950360 | 0.75 | NLRP3 (0.58) | NLRP3KCNH2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021209552-A1 | PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-21 | — | — | WO | disclosed |