Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.44 |
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | PIM1 | P11309 | 7/20 | 0.42 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25463193 | 0.91 | ACVR1 (0.40) | PIM1HTR2BHTR6CYP11B1CYP11B2 | |
| SCHEMBL23950995 | 0.90 | HTR2B (0.40) | MAPK14BRD4PIM1HTR2BHTR6 | |
| SCHEMBL25463934 | 0.90 | HTR2B (0.40) | MAPK14BRD4PIM1HTR2BHTR6 | |
| SCHEMBL23951140 | 0.87 | CYP11B1 (0.39) | PIM1HTR2BHTR6CYP11B1CYP11B2 | |
| SCHEMBL23925575 | 0.87 | CYP11B1 (0.39) | PIM1HTR2BHTR6CYP11B1CYP11B2 | |
| SCHEMBL23925713 | 0.87 | CYP11B1 (0.39) | PIM1HTR2BHTR6CYP11B1CYP11B2 | |
| SCHEMBL23925562 | 0.84 | KCNH2 (0.51) | PIM1HTR2BHTR6CYP11B1CYP11B2 | |
| SCHEMBL23950665 | 0.84 | KCNH2 (0.51) | PIM1HTR2BHTR6CYP11B1CYP11B2 | |
| SCHEMBL23925444 | 0.84 | KCNH2 (0.51) | PIM1HTR2BHTR6CYP11B1CYP11B2 | |
| SCHEMBL26286178 | 0.84 | PIM1 (0.40) | MAPK14BRD4PIM1HTR6CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115443276-B | Pyridopyrimidinone derivatives and their use as arene receptor modulators | 东亚ST株式会社 | 2025-04-18 | — | — | CN | claimed |
| CN-115443276-A | Pyridopyrimidinone derivatives and their use as modulators of aromatic hydrocarbon receptors | 东亚ST株式会社 | 2022-12-06 | — | — | CN | claimed |
| CN-115443276-B | Pyridopyrimidinone derivatives and their use as arene receptor modulators | 东亚ST株式会社 | 2025-04-18 | — | — | CN | disclosed |
| CN-115443276-A | Pyridopyrimidinone derivatives and their use as modulators of aromatic hydrocarbon receptors | 东亚ST株式会社 | 2022-12-06 | — | — | CN | disclosed |
| WO-2021210970-A1 | PYRIDOPYRIMIDINONE DERIVATIVES AND THEIR USE AS ARYL HYDROCARBON RECEPTOR MODULATORS | DONG-A ST CO., LTD. (KR) | 2021-10-21 | — | — | WO | disclosed |