Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25752450 | 0.90 | KDM4E (0.38) | CYP2C19CYP1A2CYP3A4CYP2C9L3MBTL1 | |
| SCHEMBL23950797 | 0.84 | TOP2A (0.38) | CYP2C19CYP1A2CYP3A4CYP2C9L3MBTL1 | |
| SCHEMBL25247216 | 0.81 | HTT (0.35) | CYP2C19CYP1A2CYP3A4CYP2C9L3MBTL1 | |
| SCHEMBL23950971 | 0.80 | GAA (0.33) | CYP2C19CYP1A2CYP3A4CYP2C9L3MBTL1 | |
| SCHEMBL23950194 | 0.77 | NLRP3 (0.37) | NLRP3 | |
| SCHEMBL25752270 | 0.74 | GAA (0.35) | CYP2C19CYP1A2CYP3A4CYP2C9L3MBTL1 | |
| SCHEMBL25754220 | 0.73 | NLRP3 (0.56) | NLRP3 | |
| SCHEMBL23950211 | 0.73 | NLRP3 (0.55) | CYP2C19CYP1A2CYP3A4CYP2C9L3MBTL1 | |
| SCHEMBL23950186 | 0.71 | NLRP3 (0.36) | NLRP3TOP2ATOP2B | |
| SCHEMBL25753005 | 0.69 | NLRP3 (0.51) | KMT2ANLRP3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021209552-A1 | PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-21 | — | — | WO | disclosed |