Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | WRN | Q14191 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
| ▸ | P2RY12 | Q9H244 | 8/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20132101 | 0.85 | PTGS1 (0.41) | AKT1ALDH1A1HPGD | |
| SCHEMBL16273727 | 0.83 | AKT1 (0.41) | AKT1PLK1ALDH1A1CYP1A2HPGD | |
| SCHEMBL20873310 | 0.83 | AKT1 (0.43) | AKT1ACEP2RY12 | |
| SCHEMBL15919172 | 0.83 | AKT1 (0.41) | AKT1PLK1ALDH1A1CYP1A2HPGD | |
| SCHEMBL20132290 | 0.83 | AKT1 (0.43) | AKT1ACEP2RY12 | |
| SCHEMBL31235846 | 0.82 | AKT1 (0.39) | AKT1PLK1ACEP2RY12KMT2A | |
| SCHEMBL20132239 | 0.79 | ALDH1A1 (0.36) | AKT1ALDH1A1CYP1A2HPGDCYP2C19 | |
| SCHEMBL23953445 | 0.78 | AKT1 (0.33) | AKT1 | |
| SCHEMBL31171013 | 0.78 | PTGS1 (0.38) | AKT1KMT2AREN | |
| SCHEMBL31170999 | 0.78 | PTGS1 (0.38) | AKT1KMT2AREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3901162-A1 | GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF | AbbVie Inc. (US) | 2021-10-27 | — | — | EP | disclosed |