Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.43 |
| ▸ | PGK1 | P00558 | 5/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20356648 | 0.85 | GAA (0.46) | HPGDHTTGAAATML3MBTL1 | |
| Hydrochloric Acid SCHEMBL23927528 | 0.84 | GAA (0.45) | HPGDHTTGAAATML3MBTL1 | |
| SCHEMBL23955980 | 0.84 | HPGD (0.45) | HPGDHTTGAAATML3MBTL1 | |
| SCHEMBL21526004 | 0.70 | TTR (0.43) | HPGDGAAL3MBTL1S1PR4LMNA | |
| SCHEMBL21526122 | 0.69 | S1PR4 (0.46) | HPGDHTTGAAATML3MBTL1 | |
| SCHEMBL21526018 | 0.68 | S1PR4 (0.49) | HPGDHTTGAAATML3MBTL1 | |
| SCHEMBL10642289 | 0.67 | LMNA (0.45) | HPGDGAAS1PR4LMNASLC6A4 | |
| SCHEMBL20356573 | 0.66 | GAA (0.45) | HPGDGAAL3MBTL1S1PR4SMN1; SMN2 | |
| SCHEMBL20356753 | 0.66 | TTR (0.42) | HPGDHTTGAAL3MBTL1S1PR4 | |
| SCHEMBL21526046 | 0.66 | TTR (0.47) | HPGDHTTGAAL3MBTL1S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564216-B1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2021-10-27 | — | — | EP | disclosed |