Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 9/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23957136 | 0.88 | CHRNA7 (0.44) | TRPM8EPHX2EPHX1CYP2D6CHRNA7 | |
| SCHEMBL23957152 | 0.81 | CHRNA7 (0.66) | TRPM8EPHX2CHRNA7FAAH | |
| SCHEMBL23957090 | 0.78 | CHRNA7 (0.55) | EPHX2EPHX1CYP2D6CHRNA7KCNH2 | |
| SCHEMBL23957121 | 0.78 | CHRNA7 (0.65) | EPHX2EPHX1CYP2D6CHRNA7KCNH2 | |
| SCHEMBL1912695 | 0.78 | TRPM8 (0.68) | TRPM8EPHX2EPHX1KCNH2DRD2 | |
| SCHEMBL23928852 | 0.72 | CHRNA7 (0.72) | CHRNA7 | |
| SCHEMBL1912694 | 0.72 | TRPM8 (0.73) | TRPM8EPHX2EPHX1KCNH2DRD2 | |
| SCHEMBL23957115 | 0.71 | CHRNA7 (0.76) | EPHX2EPHX1CYP2D6CHRNA7KCNH2 | |
| SCHEMBL23928897 | 0.71 | CHRNA7 (0.64) | EPHX2EPHX1CYP2D6CHRNA7KCNH2 | |
| SCHEMBL31020809 | 0.71 | CHRNA7 (0.64) | EPHX2EPHX1CYP2D6CHRNA7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210330650-A1 | SPIROCHROMANE DERIVATIVES | RICHTER GEDEON NYRT. (HU) | 2021-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210330650-A1 | SPIROCHROMANE DERIVATIVES | CHRNA7, CHRM3, ADRB3 | TRPM8 60/4885EPHX2 1079/4885EPHX1 955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.