SCHEMBL23958472

SCHEMBL23958472

C[C@@H]1Cc2cc(B(O)O)ccc2[C@@H](c2c(F)cc(OC3CN(CCCF)C3)cc2F)N1CC(F)(F)F

nearest known ligand 0.53

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 18/20 0.53
KCNH2 Q12809 6/20 0.48
GPER1 Q99527 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23958480 1.00 ESR1 (0.53) ESR1KCNH2GPER1
SCHEMBL23958462 1.00 ESR1 (0.53) ESR1KCNH2GPER1
SCHEMBL23958502 0.90 ESR1 (0.55) ESR1KCNH2GPER1
SCHEMBL23958486 0.90 ESR1 (0.55) ESR1KCNH2GPER1
SCHEMBL23958463 0.86 ESR1 (0.62) ESR1KCNH2
SCHEMBL23958458 0.86 ESR1 (0.62) ESR1KCNH2
SCHEMBL23958426 0.86 ESR1 (0.62) ESR1KCNH2
SCHEMBL23958496 0.84 ESR1 (0.42) ESR1KCNH2
SCHEMBL30822543 0.84 ESR1 (0.56) ESR1KCNH2GPER1
SCHEMBL27147351 0.84 ESR1 (0.56) ESR1KCNH2GPER1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021213358-A1 BORON-CONTAINING COMPOUNDS AND APPLICATION THEREOF 江苏先声药业有限公司 (CN) 2021-10-28 WO disclosed