SCHEMBL23958496

SCHEMBL23958496

OB(O)c1ccc2c(c1)CCN(CC(F)(F)F)C2c1c(F)cc(OC2CN(CCCF)C2)cc1F

nearest known ligand 0.42

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 19/20 0.42
HDAC6 Q9UBN7 1/20 0.39
KCNH2 Q12809 5/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19439362 0.89 ESR1 (0.51) ESR1HDAC6
SCHEMBL19439357 0.89 ESR1 (0.51) ESR1HDAC6
SCHEMBL19454190 0.89 ESR1 (0.51) ESR1HDAC6
SCHEMBL23958536 0.85 ESR1 (0.42) ESR1HDAC6KCNH2
SCHEMBL23958584 0.85 ESR1 (0.47) ESR1KCNH2
SCHEMBL23958472 0.84 ESR1 (0.53) ESR1KCNH2
SCHEMBL23958462 0.84 ESR1 (0.53) ESR1KCNH2
SCHEMBL23958480 0.84 ESR1 (0.53) ESR1KCNH2
SCHEMBL20143145 0.83 ESR1 (0.51) ESR1HDAC6
SCHEMBL20143157 0.83 ESR1 (0.51) ESR1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021213358-A1 BORON-CONTAINING COMPOUNDS AND APPLICATION THEREOF 江苏先声药业有限公司 (CN) 2021-10-28 WO disclosed