⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2382452 | 0.97 | — | — | |
| SCHEMBL15661040 | 0.90 | ALDH1A1 (0.43) | — | |
| SCHEMBL17316900 | 0.90 | — | — | |
| SCHEMBL507070 | 0.88 | ALDH1A1 (0.46) | — | |
| Hydrochloric Acid SCHEMBL19718051 | 0.88 | ALDH1A1 (0.42) | — | |
| Hydrochloric Acid SCHEMBL16225518 | 0.88 | ALDH1A1 (0.38) | — | |
| Hydrochloric Acid SCHEMBL506728 | 0.86 | ALDH1A1 (0.44) | — | |
| SCHEMBL21449654 | 0.84 | TSHR (0.37) | — | |
| SCHEMBL21449393 | 0.84 | GAA (0.31) | — | |
| Hydrochloric Acid SCHEMBL21435137 | 0.83 | GAA (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180312511-A1 | SHORT-ACTING BENZODIAZEPINE DERIVATIVES, PREPARATION METHOD THEREFOR, AND USE THEREOF | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2018-11-01 | — | — | US | claimed |
| EP-3363801-A1 | SHORT-ACTING BENZODIAZEPINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2018-08-22 | — | — | EP | claimed |
| US-20230348432-A1 | NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-02 | — | — | US | disclosed |
| US-20230348432-A1 | NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-02 | — | — | US | disclosed |
| CN-114761402-A | Novel heteroaryl-triazole compounds as pesticides | 拜耳公司 | 2022-07-15 | — | — | CN | disclosed |
| US-20220073525-A1 | COMPOSITIONS FOR INHIBITING UBIQUITIN SPECIFIC PROTEASE 1 | FORMA THERAPEUTICS, INC. (US) | 2022-03-10 | — | — | US | disclosed |
| EP-3902802-A1 | COMPOSITIONS FOR INHIBITING UBIQUITIN SPECIFIC PROTEASE 1 | Forma Therapeutics, Inc. (US) | 2021-11-03 | — | — | EP | disclosed |
| CN-113563320-A | Compound containing thiophene structure and application thereof in medicine | 天津药物研究院有限公司 | 2021-10-29 | — | — | CN | disclosed |
| CN-113474346-A | Composition for inhibiting ubiquitin-specific protease 1 | 福马治疗有限公司 | 2021-10-01 | — | — | CN | disclosed |
| US-11040968-B2 | Pyridine derivative as ASK1 inhibitor and preparation method and use thereof | FUJIAN AKEYLINK BIOTECHNOLOGY CO., LTD. (CN) | 2021-06-22 | — | — | US | disclosed |
| WO-2021105091-A1 | NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2021-06-03 | — | — | WO | disclosed |
| EP-1358165-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-05 | — | — | EP | disclosed |
| US-20030191311-A1 | A 5-(imidazol-1-yl-methyl)-pyridine derivatives for treating an NMDA-receptor-mediated disease, neurodegeneration disorder caused by stroke or brain trauma, Alzheimer's disease, Parkinson's disease, Huntington's disease | EVOTEC INTERNATIONAL GMBH (DE) | 2003-10-09 | — | — | US | disclosed |
| US-20030187268-A1 | Imidazole derivatives | EVOTEC INTERNATIONAL GMBH (DE) | 2003-10-02 | — | — | US | disclosed |
| US-6610723-B2 | Such as 3-(3,4-dimethyl-phenyl)-5-(2-methyl-imidazol-1-yl-methyl)-pyridine having affinity to N-methyl-D-aspartate-receptor subtype selective blockers; central nervous system; learning, memory, neurodegeneration | HOFFMANN-LA ROCHE INC. | 2003-08-26 | — | — | US | disclosed |
| US-20020151715-A1 | Imidazole derivatives | EVOTEC INTERNATIONAL GMBH (DE) | 2002-10-17 | — | — | US | disclosed |
| WO-2002060877-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-08 | — | — | WO | disclosed |
| US-5411980-A | Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists | MERCK & CO., INC. (US) | 1995-05-02 | — | — | US | disclosed |
| EP-0594605-A1 | 1-AZABICYCLIC COMPOUNDS, PROCESSES AND PHARMACEUTICAL COMPOSITONS CONTAINING THEM | Beecham Group p.l.c. (GB) | 1994-05-04 | — | — | EP | disclosed |
| WO-1991013885-A1 | 1-AZABICYCLIC COMPOUNDS, PROCESSES AND PHARMACEUTICAL COMPOSITONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1991-09-19 | — | — | WO | disclosed |