Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCTR | P47872 | 9/20 | 0.58 |
| ▸ | SMO | Q99835 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31402481 | 0.73 | SCTR (0.75) | SCTRSMO | |
| SCHEMBL16367807 | 0.72 | SCTR (0.89) | SCTRSMO | |
| Purmorphamine SCHEMBL1548273 | 0.70 | SCTR (1.00) | SCTRSMO | |
| Purmorphamine SCHEMBL29358352 | 0.70 | SCTR (1.00) | SCTRSMO | |
| SCHEMBL14075696 | 0.69 | SCTR (0.98) | SCTRSMO | |
| SCHEMBL28300768 | 0.69 | AURKA (0.44) | ALDH1A1AURKAJAK2PRKCAJAK1 | |
| SCHEMBL24978893 | 0.68 | HTR1B (0.38) | CYP1A2ALDH1A1CYP2C19 | |
| SCHEMBL14743315 | 0.67 | ADORA2A (0.49) | CYP1A2ALDH1A1AURKAJAK2PRKCA | |
| SCHEMBL27438642 | 0.67 | PI4KA (0.42) | ALDH1A1AURKAJAK2PRKCAJAK1 | |
| SCHEMBL28234948 | 0.64 | ADORA2A (0.42) | ALDH1A1AURKAJAK2PRKCAJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021216623-A1 | GENE EDITING OF LRRK2 IN STEM CELLS AND METHOD OF USE OF CELLS DIFFERENTIATED THEREFROM | ASPEN NEUROSCIENCE, INC. (US) | 2021-10-28 | — | — | WO | disclosed |