Purmorphamine

Purmorphamine

SCHEMBL29358352

c1ccc2c(Oc3nc(Nc4ccc(N5CCOCC5)cc4)c4ncn(C5CCCCC5)c4n3)cccc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
SCTR P47872 9/20 1.00
SMO Q99835 1/20 1.00
FLT3 P36888 10/20 0.57
PDGFRA P16234 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Purmorphamine SCHEMBL1548273 1.00 SCTR (1.00) SCTRSMOFLT3PDGFRA
SCHEMBL14075696 0.99 SCTR (0.98) SCTRSMOFLT3PDGFRA
SCHEMBL14075697 0.98 SCTR (0.95) SCTRSMOFLT3PDGFRA
SCHEMBL16367807 0.94 SCTR (0.89) SCTRSMOFLT3PDGFRA
SCHEMBL14075700 0.87 SCTR (0.76) SCTRSMOFLT3
SCHEMBL14707305 0.86 SCTR (0.76) SCTRSMOFLT3PDGFRA
SCHEMBL31402481 0.86 SCTR (0.75) SCTRSMOFLT3PDGFRA
SCHEMBL14075691 0.85 SCTR (0.74) SCTRSMOFLT3PDGFRA
SCHEMBL14075692 0.85 SCTR (0.74) SCTRSMOFLT3PDGFRA
SCHEMBL14075698 0.84 SCTR (0.72) SCTRSMO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1224 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260132374-A1 Compositions and Methods for Efficient Amplification of Retinal Progenitors Cells SORBONNE UNIVERSITE (FR) 2026-05-14 US claimed
US-20260115318-A1 GENE CORRECTION INDUCED NEURAL STEM CELLS USING HUNTINGTIN GENE-SPECIFIC GUIDE RNA, AND CELL THERAPEUTIC AGENT USING THE SAME KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) 2026-04-30 US claimed
EP-3868873-B1 PRODUCTION METHOD FOR RETINAL TISSUE RACTHERA CO LTD (JP) 2026-04-29 EP claimed
EP-4728055-A2 METHODS FOR DIFFERENTIATING DOPAMINERGIC NEURONS FROM STEM CELLS Aspen Neuroscience, Inc. (US) 2026-04-22 EP claimed
EP-3768222-B1 REGENERATION OF VITAL TOOTH PULP UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION (US) 2026-04-22 EP claimed
US-12600943-B2 Innervated organoid compositions and methods of making same THE UNIVERSITY OF HONG KONG 2026-04-14 US claimed
US-12590954-B2 Neural stem cell-induced differential medium and induction differentiation method IREGENE THERAPEUTICS, CO., LTD. (CN) 2026-03-31 US claimed
EP-4711447-A1 MEDIUM COMPOSITION FOR CULTURING NEUROMUSCULAR ORGANOID AND METHOD FOR PRODUCING NEUROMUSCULAR ORGANOID Animuscure Inc. (KR) 2026-03-18 EP claimed
US-12565639-B2 Methods for differentiating dopaminergic neurons from stem cells ASPEN NEUROSCIENCE, INC. (US) 2026-03-03 US claimed
US-12533383-B2 Method for producing cell aggregate including glial progenitor cells KEIO UNIVERSITY (JP) 2026-01-27 US claimed
US-20220112457-A1 PRODUCTION METHOD FOR NERVE TISSUE SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2022-04-14 US claimed
CN-114262686-A Preparation method and application of oligodendrocyte 深圳市夏同生物医药科技有限公司 2022-04-01 CN claimed
US-20220098550-A1 METHOD FOR MANUFACTURING TELENCEPHALON OR PROGENITOR TISSUE THEREOF RIKEN (JP) 2022-03-31 US claimed
US-20220090011-A1 INNERVATED ORGANOID COMPOSITIONS AND METHODS OF MAKING SAME CHILDREN'S HOSPITAL MEDICAL CENTER 2022-03-24 US claimed
WO-2022060466-A1 COMPOUNDS, TARGETS AND PATHWAYS FOR MACROPHAGE MODULATION MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2022-03-24 WO claimed
US-20220087950-A1 COMPOUNDS, TARGETS AND PATHWAYS FOR MACROPHAGE MODULATION NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-03-24 US claimed
WO-2022037570-A1 EXPANSION CULTURE MEDIUM AND CULTURE METHOD FOR NEURAL CELLS 中国科学院动物研究所 2022-02-24 WO claimed
EP-3303564-B1 METHODS OF IN VITRO DIFFERENTIATION OF MIDBRAIN DOPAMINE (MDA) NEURONS MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2022-02-23 EP claimed
EP-3954763-A1 METHOD FOR PRODUCING ADENOHYPOPHYSIS OR PRECURSOR TISSUE THEREOF RIKEN (JP) 2022-02-16 EP claimed
CN-108865997-B Culture medium and culture method for in vitro culture of astrocytes 华南师范大学 2022-02-11 CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12533383-B2 Method for producing cell aggregate including glial progenitor cells BMP4, WNT3A, BMPR2 SCTR 1721/4885SMO 11/4885FLT3 3841/4885
US-12600943-B2 Innervated organoid compositions and methods of making same GLI2, PAX2, CHRNB2 SCTR 530/4885SMO 19/4885FLT3 3076/4885
US-20260115318-A1 GENE CORRECTION INDUCED NEURAL STEM CELLS USING HUNTINGTIN GENE-SPECIFIC GUIDE RNA, AND CELL THERAPEUTIC AGENT USING THE SAME HTT, NES, NSUN3 SCTR 4349/4885SMO 1054/4885FLT3 2435/4885
US-20260132374-A1 Compositions and Methods for Efficient Amplification of Retinal Progenitors Cells IGF1R, NR2E3, TFEB SCTR 215/4885SMO 34/4885FLT3 261/4885
US-12590954-B2 Neural stem cell-induced differential medium and induction differentiation method SMAD3, SALL4, BMP4 SCTR 1195/4885SMO 64/4885FLT3 820/4885
US-12565639-B2 Methods for differentiating dopaminergic neurons from stem cells GSK3B, WNT3A, GSK3A SCTR 4042/4885SMO 34/4885FLT3 2523/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.