Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP4 | P12644 | 7/20 | 0.69 |
| ▸ | ACVR1 | Q04771 | 14/20 | 0.67 |
| ▸ | ACVR1B | P36896 | 13/20 | 0.67 |
| ▸ | ACVRL1 | P37023 | 12/20 | 0.67 |
| ▸ | BMPR1B | O00238 | 11/20 | 0.67 |
| ▸ | BMPR1A | P36894 | 10/20 | 0.67 |
| ▸ | KDR | P35968 | 7/20 | 0.67 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.67 |
| ▸ | PRKAB1 | Q9Y478 | 6/20 | 0.67 |
| ▸ | TGFBR2 | P37173 | 4/20 | 0.67 |
| ▸ | BMPR2 | Q13873 | 3/20 | 0.61 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.59 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.59 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21156307 | 0.90 | ACVR1 (0.62) | BMP4ACVR1ACVR1BACVRL1BMPR1B | |
| SCHEMBL12779920 | 0.83 | BMP4 (0.82) | BMP4ACVR1ACVR1BACVRL1BMPR1B | |
| SCHEMBL11953449 | 0.83 | BMP4 (1.00) | BMP4ACVR1ACVR1BACVRL1BMPR1B | |
| SCHEMBL17538467 | 0.82 | BMP4 (0.63) | BMP4ACVR1ACVR1BACVRL1BMPR1B | |
| SCHEMBL11953445 | 0.81 | BMP4 (1.00) | BMP4ACVR1ACVR1BACVRL1BMPR1B | |
| SCHEMBL17531593 | 0.81 | BMP4 (0.82) | BMP4ACVR1ACVR1BACVRL1BMPR1B | |
| SCHEMBL12779978 | 0.81 | BMP4 (0.82) | BMP4ACVR1ACVR1BACVRL1BMPR1B | |
| SCHEMBL11953447 | 0.80 | BMP4 (1.00) | BMP4ACVR1ACVR1BACVRL1BMPR1B | |
| SCHEMBL14671967 | 0.80 | ACVR1 (1.00) | BMP4ACVR1ACVR1BACVRL1BMPR1B | |
| SCHEMBL29700879 | 0.80 | ACVR1 (1.00) | BMP4ACVR1ACVR1BACVRL1BMPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021216623-A1 | GENE EDITING OF LRRK2 IN STEM CELLS AND METHOD OF USE OF CELLS DIFFERENTIATED THEREFROM | ASPEN NEUROSCIENCE, INC. (US) | 2021-10-28 | — | — | WO | disclosed |