SCHEMBL239629

SCHEMBL239629

Fc1ccc(C2CCN(c3c(F)cc(N4[C@@H](c5cc6[nH]c([C@@H]7CCCN7)nc6cc5F)CC[C@@H]4c4cc5[nH]c([C@@H]6CCCN6)nc5cc4F)cc3F)CC2)cc1

nearest known ligand 0.60

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SCN10A Q9Y5Y9 1/20 0.38
MPO P05164 1/20 0.32
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20639342 1.00 SCN10A (0.38) SCN10AMPOKMT2A
SCHEMBL238095 0.93 SCN10A (0.38) SCN10A
SCHEMBL15452940 0.93 SCN10A (0.38) SCN10A
SCHEMBL2278873 0.93 SCN10A (0.38) SCN10A
SCHEMBL241229 0.92 SCN10A (0.38) SCN10AMPO
SCHEMBL239849 0.90 SCN10A (0.36) SCN10AKMT2A
SCHEMBL20694958 0.90 SCN10A (0.43) SCN10AMPO
SCHEMBL241559 0.90 SCN10A (0.43) SCN10AMPO
SCHEMBL239572 0.88 SCN10A (0.41) SCN10A
SCHEMBL242113 0.88 SCN10A (0.41) SCN10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3438106-A1 ANTI-VIRAL COMPOUNDS AbbVie Ireland Unlimited Company (IE) 2019-02-06 EP claimed
US-20190015402-A1 Anti-Viral Compounds ABBVIE INC. (US) 2019-01-17 US claimed
US-20230285378-A1 Anti-Viral Compounds ABBVIE INC. (US) 2023-09-14 US disclosed
US-20210171506-A1 Process for Manufacturing Pibrentasvir Active Drug Substance ABBVIE INC. (US) 2021-06-10 US disclosed
US-20210171506-A1 Process for Manufacturing Pibrentasvir Active Drug Substance ABBVIE INC. (US) 2021-06-10 US disclosed
CN-112638368-A Process for the manufacture of piretavir active pharmaceutical substance 艾伯维公司 2021-04-09 CN disclosed
WO-2020047182-A1 PROCESS FOR MANUFACTURING PIBRENTASVIR ACTIVE DRUG SUBSTANCE ABBVIE INC. (US) 2020-03-05 WO disclosed
EP-3438106-A1 ANTI-VIRAL COMPOUNDS AbbVie Ireland Unlimited Company (IE) 2019-02-06 EP disclosed
US-20190015402-A1 Anti-Viral Compounds ABBVIE INC. (US) 2019-01-17 US disclosed
US-10039754-B2 Anti-viral compounds ABBVIE INC. (US) 2018-08-07 US disclosed
US-10028937-B2 Anti-viral compounds ABBVIE INC. (US) 2018-07-24 US disclosed
EP-2692346-B1 An antiviral 1-phenyl-2,5-dibenzimidazol-5-yl-pyrrolidine derivative ABBVIE BAHAMAS LTD (BS) 2015-12-02 EP disclosed
US-20150087618-A1 Anti-Viral Compounds ABBVIE INC. (US) 2015-03-26 US disclosed
US-8937150-B2 Anti-viral compounds ABBVIE INC. (US) 2015-01-20 US disclosed
US-8921514-B2 Anti-viral compounds ABBVIE INC. (US) 2014-12-30 US disclosed
EP-2692346-A1 An antiviral 1-phenyl-2,5-dibenzimidazol-5-yl-pyrrolidine derivative Abbvie Inc. (US) 2014-02-05 EP disclosed
EP-2692726-A1 Anti-viral compounds Abbvie Inc. (US) 2014-02-05 EP disclosed
US-20120220562-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2012-08-30 US disclosed
US-20120004196-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2012-01-05 US disclosed
US-20110207699-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2011-08-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10028937-B2 Anti-viral compounds HAVCR2, EIF2AK2, MAVS SCN10A 4583/4885MPO 762/4885KMT2A 4093/4885
US-20230285378-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS SCN10A 4583/4885MPO 762/4885KMT2A 4093/4885
US-20120220562-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS SCN10A 4583/4885MPO 762/4885KMT2A 4093/4885
US-20150087618-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS SCN10A 4583/4885MPO 762/4885KMT2A 4093/4885
US-20110207699-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS SCN10A 4583/4885MPO 762/4885KMT2A 4093/4885
US-20210171506-A1 Process for Manufacturing Pibrentasvir Active Drug Substance CYP3A5, CYP3A4, HAVCR2 SCN10A 4397/4885MPO 3910/4885KMT2A 2672/4885
US-20190015402-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS SCN10A 4583/4885MPO 762/4885KMT2A 4093/4885
US-20120004196-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS SCN10A 4583/4885MPO 762/4885KMT2A 4093/4885
US-10039754-B2 Anti-viral compounds HAVCR2, EIF2AK2, MAVS SCN10A 4583/4885MPO 762/4885KMT2A 4093/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.