Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 16/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2398019 | 0.90 | PIK3CD (0.39) | ADORA3ADORA2AADORA1PIK3CDPIK3CA | |
| SCHEMBL2396456 | 0.90 | PIK3CD (0.39) | ADORA3ADORA2AADORA1PIK3CDPIK3CA | |
| SCHEMBL2397516 | 0.86 | ADORA3 (0.45) | ADORA3ADORA2AADORA1PIK3CDPIK3CA | |
| SCHEMBL48887 | 0.81 | PIK3CG (0.64) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL2398905 | 0.80 | PIK3CD (0.63) | ADORA3ADORA2AADORA1PIK3CDPIK3CA | |
| SCHEMBL2396335 | 0.77 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CGPIK3CBLCK | |
| SCHEMBL2398117 | 0.76 | PIK3CD (0.50) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL2399363 | 0.74 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CGPIK3CBCLK1 | |
| SCHEMBL2398032 | 0.74 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL2395910 | 0.72 | MEN1 (0.60) | PIK3CDPIK3CAPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017608-B2 | 5-Phenylthiazole derivatives and their use as p13 kinase inhibitors | NOVARTIS AG (CH) | 2011-09-13 | — | — | US | disclosed |
| EP-1608647-B1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-01-09 | — | — | EP | disclosed |