Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2396790 | 0.77 | PIK3CD (0.41) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL2396380 | 0.76 | PIK3CD (0.62) | PIK3CACLK1PIK3CDPIK3CBPIK3CG | |
| Bromide SCHEMBL2398769 | 0.75 | PIK3CD (0.61) | PIK3CACLK1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL2397564 | 0.73 | PIK3CD (0.64) | PIK3CACLK1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL1889933 | 0.73 | CDK2 (0.43) | AURKAADORA2A | |
| SCHEMBL2398723 | 0.71 | PIK3CD (0.41) | PIK3CACLK1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL2399363 | 0.71 | PIK3CD (0.38) | PIK3CACLK1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL2398248 | 0.71 | PIK3CD (0.40) | PIK3CACLK1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL2398780 | 0.69 | PIK3CA (0.53) | PIK3CANPC1ALDH1A1TSHRCLK1 | |
| SCHEMBL2397832 | 0.67 | MEN1 (0.61) | PIK3CANPC1ALDH1A1RAB9APIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017608-B2 | 5-Phenylthiazole derivatives and their use as p13 kinase inhibitors | NOVARTIS AG (CH) | 2011-09-13 | — | — | US | disclosed |
| EP-1608647-B1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-01-09 | — | — | EP | disclosed |