Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.34 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | LITAF | Q99732 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31679008 | 0.89 | ABL1 (0.36) | PIK3CAAURKARPS6KB1PIK3CBPIK3C2A | |
| SCHEMBL22183701 | 0.88 | HPGDS (0.34) | MTORPIK3CAHDAC1HDAC6P4HTM | |
| SCHEMBL22163834 | 0.86 | PIK3CA (0.34) | MTORPIK3CAHDAC1HDAC6AURKA | |
| SCHEMBL22163856 | 0.85 | CDK4 (0.36) | MTORPIK3CAPIK3CBSMN1; SMN2TNF | |
| SCHEMBL22183764 | 0.85 | PIK3CB (0.39) | MTORPIK3CAHDAC1P4HTMAURKA | |
| SCHEMBL22163832 | 0.85 | CSF1R (0.33) | MTORPIK3CAHDAC1HDAC6P4HTM | |
| SCHEMBL23966097 | 0.85 | PIK3CB (0.39) | MTORPIK3CAHDAC1P4HTMPIK3CB | |
| SCHEMBL24211128 | 0.84 | PIK3CB (0.38) | MTORPIK3CAHDAC1PIK3CBPIK3C2A | |
| SCHEMBL22183752 | 0.84 | PIK3CB (0.39) | MTORPIK3CAHDAC1HDAC6P4HTM | |
| SCHEMBL22183756 | 0.84 | PIK3CB (0.41) | MTORPIK3CAHDAC1HDAC6PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220017505-A1 | AMINOQUINAZOLINONE AND AMINOISOQUINOLINONE DERIVATIVES AND APPLICATION THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2022-01-20 | — | — | US | disclosed |
| EP-3904343-A1 | AMINO QUINAZOLINONE, AMINO ISOQUINOLONE DERIVATIVES AND APPLICATION THEREOF | Zhejiang University (CN) | 2021-11-03 | — | — | EP | disclosed |
| CN-109516961-B | Aminoquinazolinone and aminoisoquinolinone derivatives and uses thereof | 浙江大学 | 2021-01-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220017505-A1 | AMINOQUINAZOLINONE AND AMINOISOQUINOLINONE DERIVATIVES AND APPLICATION THEREOF | PIK3R5, PIK3CA, PIK3R1 | MTOR 14/4885PIK3CA 2/4885HDAC1 3070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.