Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 11/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | EED | O75530 | 2/20 | 0.36 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.36 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.36 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18865683 | 0.79 | GRM1 (0.52) | GRM5GRM1GPR119PDK4NAMPT | |
| SCHEMBL18886595 | 0.77 | GRM5 (0.43) | GRM5GRM1GPR119PDK4NAMPT | |
| SCHEMBL2002272 | 0.76 | PDK4 (0.48) | GRM5GRM1GPR119PDK4NAMPT | |
| SCHEMBL12566963 | 0.76 | PDK4 (0.48) | GRM5GRM1GPR119PDK4NAMPT | |
| SCHEMBL18886596 | 0.76 | GRM1 (0.41) | GRM5GRM1GPR119PDK4NAMPT | |
| SCHEMBL2349369 | 0.75 | PDK4 (0.47) | GRM5GRM1GPR119PDK4NAMPT | |
| SCHEMBL28161050 | 0.75 | PDK4 (0.47) | GRM5GRM1GPR119PDK4NAMPT | |
| SCHEMBL12074148 | 0.75 | PDK4 (0.47) | GRM5GRM1GPR119PDK4NAMPT | |
| SCHEMBL6662189 | 0.75 | PDK4 (0.47) | GRM5GRM1GPR119PDK4NAMPT | |
| SCHEMBL2003552 | 0.75 | PDK4 (0.47) | GRM5GRM1GPR119PDK4NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11161848-B2 | Purinones as ubiquitin-specific protease 1 inhibitors | FORMA THERAPEUTICS, INC. (US) | 2021-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11161848-B2 | Purinones as ubiquitin-specific protease 1 inhibitors | USP1, UBA1, UBXN1 | GRM5 3487/4885GRM1 1846/4885GPR119 3570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.