Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 20/20 | 0.68 |
| ▸ | FGFR2 | P21802 | 20/20 | 0.68 |
| ▸ | FGFR3 | P22607 | 20/20 | 0.68 |
| ▸ | FGFR4 | P22455 | 18/20 | 0.68 |
| ▸ | KDR | P35968 | 17/20 | 0.68 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.68 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.68 |
| ▸ | DRD3 | P35462 | 1/20 | 0.68 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.68 |
| ▸ | ETV6 | P41212 | 1/20 | 0.68 |
| ▸ | HTR2B | P41595 | 1/20 | 0.68 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.68 |
| ▸ | FLT3 | P36888 | 11/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14901133 | 0.94 | FGFR1 (0.76) | FGFR1FGFR2FGFR3FGFR4KDR | |
| SCHEMBL14901164 | 0.83 | FGFR3 (0.74) | FGFR1FGFR2FGFR3FGFR4KDR | |
| SCHEMBL14901182 | 0.83 | FGFR3 (0.78) | FGFR1FGFR2FGFR3FGFR4KDR | |
| SCHEMBL18021081 | 0.82 | FGFR3 (0.73) | FGFR1FGFR2FGFR3FGFR4KDR | |
| SCHEMBL16125208 | 0.82 | FGFR3 (0.75) | FGFR1FGFR2FGFR3FGFR4KDR | |
| SCHEMBL14901309 | 0.82 | FGFR1 (0.77) | FGFR1FGFR2FGFR3FGFR4KDR | |
| SCHEMBL23667656 | 0.81 | FGFR1 (0.71) | FGFR1FGFR2FGFR3FGFR4KDR | |
| SCHEMBL14905516 | 0.81 | FGFR1 (1.00) | FGFR1FGFR2FGFR3FGFR4KDR | |
| Erdafitinib SCHEMBL2583760 | 0.81 | FGFR1 (1.00) | FGFR1FGFR2FGFR3FGFR4KDR | |
| Erdafitinib SCHEMBL29359988 | 0.81 | FGFR1 (1.00) | FGFR1FGFR2FGFR3FGFR4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3353164-B1 | BI-HETEROARYL SUBSTITUTED 1,4-BENZODIAZEPINES AND USES THEREOF FOR THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA NV (BE) | 2021-11-03 | — | — | EP | disclosed |