Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | GALR3 | O60755 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23909032 | 0.92 | HTT (0.36) | HTTHSD17B10ARTDP1P2RX3 | |
| SCHEMBL23915348 | 0.91 | HSD17B10 (0.36) | HTTHSD17B10ARTDP1P2RX3 | |
| SCHEMBL23966538 | 0.91 | HTT (0.36) | HTTHSD17B10ARTDP1P2RX3 | |
| SCHEMBL23914625 | 0.89 | HTT (0.36) | HTTHSD17B10ARTDP1P2RX3 | |
| SCHEMBL23915349 | 0.89 | HSD17B10 (0.36) | HTTHSD17B10ARTDP1P2RX3 | |
| SCHEMBL23909123 | 0.79 | S1PR2 (0.40) | HTTHSD17B10ARTDP1P2RX3 | |
| SCHEMBL23908833 | 0.69 | S1PR2 (0.44) | LMNATSHRALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL23908886 | 0.68 | PARP1 (0.36) | ARLMNATSHRNPC1 | |
| SCHEMBL23915472 | 0.66 | XDH (0.32) | — | |
| SCHEMBL23966523 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649119-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2021-11-03 | — | — | EP | disclosed |