Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.32 |
| ▸ | KLK7 | P49862 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24960540 | 0.88 | TRPM8 (0.36) | TRPM8NPC1RAB9AGAAALDH1A1 | |
| SCHEMBL22818952 | 0.84 | NR1I2 (0.35) | TRPM8NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL24959856 | 0.83 | TRPM8 (0.38) | TRPM8NPC1RAB9AGAAALDH1A1 | |
| SCHEMBL12310758 | 0.81 | TRPM8 (0.44) | TRPM8NPC1RAB9AGAAALDH1A1 | |
| SCHEMBL12261480 | 0.79 | TRPM8 (0.38) | TRPM8NPC1RAB9AGAAALDH1A1 | |
| SCHEMBL12261482 | 0.79 | TRPM8 (0.38) | TRPM8NPC1RAB9AGAAALDH1A1 | |
| SCHEMBL24027291 | 0.78 | TRPM8 (0.41) | TRPM8NPC1RAB9AGAAALDH1A1 | |
| SCHEMBL23565935 | 0.77 | NPC1 (0.34) | TRPM8NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL23339950 | 0.77 | NPC1 (0.34) | TRPM8NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL23966695 | 0.77 | KDM4E (0.32) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252488-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. (US) | 2021-12-16 | — | — | WO | disclosed |
| WO-2021242505-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. (US) | 2021-12-02 | — | — | WO | disclosed |
| US-11161852-B1 | Inhibitors of NEK7 kinase | Halia Therapeutics, Inc. (US) | 2021-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11161852-B1 | Inhibitors of NEK7 kinase | NEK7, NEK1, NEK5 | TRPM8 1239/4885NPC1 414/4885RAB9A 2987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.