⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4785366 | 0.84 | ALDH1A1 (0.32) | — | |
| SCHEMBL3070460 | 0.81 | — | — | |
| SCHEMBL3065903 | 0.79 | — | — | |
| SCHEMBL3077441 | 0.79 | — | — | |
| SCHEMBL402279 | 0.79 | — | — | |
| SCHEMBL4526969 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL28556945 | 0.78 | KLK1 (0.30) | — | |
| Hydrochloric Acid SCHEMBL29794674 | 0.78 | CYP1A2 (0.37) | — | |
| SCHEMBL3064600 | 0.72 | — | — | |
| SCHEMBL11323653 | 0.72 | IDO1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4214197-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | Nura Bio, Inc. (US) | 2023-07-26 | — | — | EP | disclosed |
| CN-109970760-B | ACC inhibitors and uses thereof | 吉利德阿波罗公司 | 2022-04-26 | — | — | CN | disclosed |
| WO-2022060812-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | NURA BIO, INC. (US) | 2022-03-24 | — | — | WO | disclosed |
| CN-109096194-B | Biguanide derivative, pharmaceutical composition, preparation method and application | 湖南师范大学 | 2022-02-08 | — | — | CN | disclosed |
| CN-109320508-B | Compound with isothiazolinone and N-arylpyrazole structure and preparation method and application thereof | 南京工业大学 | 2020-07-17 | — | — | CN | disclosed |
| CN-109096194-A | A kind of Biguanide derivative, pharmaceutical composition, preparation method and purposes | 湖南师范大学 | 2018-12-28 | — | — | CN | disclosed |
| EP-1888546-B1 | THIAZOLE DERIVATIVES AND USE THEREOF | MERCK SERONO SA (CH) | 2015-07-08 | — | — | EP | disclosed |
| CN-103113304-A | Pyrazole thiourea derivative as well as preparation method and application thereof | UNIV ANHUI AGRICULTURAL | 2013-05-22 | — | — | CN | disclosed |
| CN-103113304-A | Pyrazole thiourea derivative as well as preparation method and application thereof | UNIV ANHUI AGRICULTURAL | 2013-05-22 | — | — | CN | disclosed |
| CN-103113304-A | Pyrazole thiourea derivative as well as preparation method and application thereof | UNIV ANHUI AGRICULTURAL | 2013-05-22 | — | — | CN | disclosed |
| EP-1353674-A1 | METHOD FOR TREATING GLAUCOMA IVB | Alteon, Inc. (US) | 2003-10-22 | — | — | EP | disclosed |
| US-6596745-B2 | Fibrosis therapy | ALTEON, INC. | 2003-07-22 | — | — | US | disclosed |
| US-20030004194-A1 | Method for treating fibrotic diseases or other indications VI | ALTEON, INC. (US) | 2003-01-02 | — | — | US | disclosed |
| US-20030004195-A1 | Method for treating glaucoma VI | ALTEON, INC. (US) | 2003-01-02 | — | — | US | disclosed |
| WO-2002096362-A2 | METHOD FOR TREATING FIBROTIC DISEASES OR OTHER INDICATIONS VI | ALTEON INC. (US) | 2002-12-05 | — | — | WO | disclosed |
| WO-2002096317-A2 | METHOD FOR TREATING GLAUCOMA VI | ALTEON, INC. (US) | 2002-12-05 | — | — | WO | disclosed |
| US-20020156073-A1 | Method for treating glaucoma IVB | ALTEON, INC. | 2002-10-24 | — | — | US | disclosed |
| US-20020107245-A1 | Method for treating fibrotic diseases or other indications IVC | ALTEON, INC. | 2002-08-08 | — | — | US | disclosed |
| WO-2002053101-A2 | METHOD FOR TREATING FIBROTIC DISEASES OR OTHER INDICATIONS | ALTEON, INC. (US) | 2002-07-11 | — | — | WO | disclosed |
| WO-2002053160-A1 | METHOD FOR TREATING GLAUCOMA IVB | ALTEON, INC. (US) | 2002-07-11 | — | — | WO | disclosed |