Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 12/20 | 0.87 |
| ▸ | TSHR | P16473 | 8/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.60 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9851657 | 0.91 | CYP2D6 (0.81) | CYP2D6TSHRCYP3A4ALDH1A1CHRM2 | |
| SCHEMBL23642169 | 0.85 | CYP2D6 (0.65) | CYP2D6TSHRCYP3A4ALDH1A1CHRM2 | |
| SCHEMBL23642168 | 0.85 | CYP2D6 (0.65) | CYP2D6TSHRCYP3A4ALDH1A1CHRM2 | |
| SCHEMBL4692167 | 0.84 | CYP2D6 (0.70) | CYP2D6TSHRCYP3A4ALDH1A1CHRM2 | |
| SCHEMBL1732446 | 0.83 | CYP2D6 (0.65) | CYP2D6TSHRCYP3A4ALDH1A1USP2 | |
| SCHEMBL4927933 | 0.82 | CYP2D6 (0.69) | CYP2D6TSHRCYP3A4ALDH1A1CHRM2 | |
| SCHEMBL8060461 | 0.82 | CYP2D6 (0.67) | CYP2D6TSHRCYP3A4ALDH1A1CHRM2 | |
| SCHEMBL5243003 | 0.81 | CYP2D6 (0.67) | CYP2D6TSHRCYP3A4ALDH1A1USP2 | |
| SCHEMBL19320647 | 0.80 | MC4R (0.61) | CYP2D6TSHRCYP3A4ALDH1A1MEN1 | |
| SCHEMBL16600547 | 0.80 | CYP2D6 (0.66) | CYP2D6TSHRCYP3A4ALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11161856-B2 | Spirocycle compounds and methods of making and using same | H. LUNDBECK A/S (DK) | 2021-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11161856-B2 | Spirocycle compounds and methods of making and using same | OPRL1, MGLL, VKORC1L1 | CYP2D6 459/4885TSHR 4381/4885CYP3A4 2792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.