Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | BRAF | P15056 | 3/20 | 0.33 |
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9416889 | 0.82 | EGFR (0.33) | EGFRMAPK14SMN1; SMN2TDP1NPC1 | |
| SCHEMBL8765157 | 0.82 | CNR1 (0.35) | EGFRMAPK14SMN1; SMN2TDP1NPC1 | |
| SCHEMBL4717576 | 0.79 | EGFR (0.51) | EGFRMAPK14SMN1; SMN2TDP1NPC1 | |
| SCHEMBL20922052 | 0.79 | MAPK14 (0.50) | EGFRMAPK14KITNPC1RAB9A | |
| SCHEMBL1078864 | 0.78 | NPC1 (0.48) | EGFRMAPK14SMN1; SMN2TDP1KIT | |
| SCHEMBL28314210 | 0.76 | EGFR (0.47) | EGFRMAPK14SMN1; SMN2TDP1KIT | |
| SCHEMBL12650126 | 0.76 | HCAR2 (0.35) | MEN1KMT2ACNR2 | |
| SCHEMBL1013121 | 0.74 | MEN1 (0.31) | KITMEN1KMT2A | |
| SCHEMBL23966693 | 0.74 | ALDH1A1 (0.38) | EGFRMAPK14MEN1KMT2ACNR1 | |
| SCHEMBL21479384 | 0.74 | EGFR (0.44) | EGFRMAPK14SMN1; SMN2TDP1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3904355-A1 | SUBSTITUTED FUSED AROMATIC RING DERIVATIVE, COMPOSITION AND USE THEREOF | Shenzhen TargetRx, Inc. (CN) | 2021-11-03 | — | — | EP | disclosed |