Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.58 |
| ▸ | DRD1 | P21728 | 7/20 | 0.53 |
| ▸ | DRD5 | P21918 | 6/20 | 0.53 |
| ▸ | DRD2 | P14416 | 5/20 | 0.53 |
| ▸ | DRD3 | P35462 | 5/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21524785 | 0.90 | HSD17B10 (0.58) | NOTUMDRD1DRD5DRD2DRD3 | |
| SCHEMBL19676543 | 0.86 | DRD1 (0.53) | NOTUMDRD1DRD5DRD2DRD3 | |
| SCHEMBL2625807 | 0.80 | NOTUM (0.59) | NOTUMDRD1DRD5DRD2DRD3 | |
| SCHEMBL4105407 | 0.79 | NOTUM (0.58) | NOTUMDRD1DRD5DRD2DRD3 | |
| SCHEMBL23975613 | 0.78 | DRD1 (0.66) | NOTUMDRD1DRD5DRD2DRD3 | |
| SCHEMBL12905308 | 0.77 | NOTUM (0.56) | NOTUMDRD1DRD5DRD2DRD3 | |
| SCHEMBL2632805 | 0.76 | NOTUM (0.55) | NOTUMDRD1DRD5DRD2DRD3 | |
| SCHEMBL22021589 | 0.76 | NOTUM (0.55) | NOTUMDRD1DRD5DRD2DRD3 | |
| SCHEMBL17854037 | 0.76 | NOTUM (0.55) | NOTUMDRD1DRD5DRD2DRD3 | |
| SCHEMBL12488221 | 0.76 | SRD5A1 (0.56) | NOTUMDRD1DRD5DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |