Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 9/20 | 0.66 |
| ▸ | DRD5 | P21918 | 8/20 | 0.66 |
| ▸ | DRD2 | P14416 | 8/20 | 0.66 |
| ▸ | DRD3 | P35462 | 8/20 | 0.66 |
| ▸ | DRD4 | P21917 | 5/20 | 0.63 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3698679 | 0.86 | DRD1 (0.86) | DRD1DRD5DRD2DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL10702384 | 0.85 | DRD1 (0.83) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL2607471 | 0.83 | DRD1 (0.62) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL15025091 | 0.83 | DRD1 (0.64) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL14340583 | 0.81 | DRD1 (0.88) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL29515933 | 0.81 | DRD1 (0.88) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL15088517 | 0.80 | HRH3 (0.61) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL11823744 | 0.80 | DRD1 (0.85) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL24702127 | 0.80 | DRD1 (0.60) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL11819711 | 0.80 | DRD1 (0.85) | DRD1DRD5DRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |