Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | OGA | O60502 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14479660 | 1.00 | ALDH1A1 (0.59) | ALDH1A1GAAMAPK1HSD17B10OGA | |
| SCHEMBL11518498 | 0.81 | S1PR1 (0.41) | ALDH1A1GAAMAPK1HSD17B10OGA | |
| SCHEMBL12263521 | 0.81 | HSD17B10 (0.49) | ALDH1A1GAAMAPK1HSD17B10OGA | |
| Hydrochloric Acid SCHEMBL26599735 | 0.79 | S1PR1 (0.40) | ALDH1A1GAAMAPK1HSD17B10OGA | |
| SCHEMBL12263529 | 0.79 | PIK3CD (0.46) | ALDH1A1GAAOGAHRH3MAPT | |
| SCHEMBL21737951 | 0.76 | ALDH1A1 (0.61) | ALDH1A1GAAMAPK1HSD17B10HRH3 | |
| SCHEMBL5631018 | 0.74 | ALDH1A1 (1.00) | ALDH1A1GAAMAPK1HSD17B10OGA | |
| SCHEMBL11372459 | 0.74 | ALDH1A1 (1.00) | ALDH1A1GAAMAPK1HSD17B10OGA | |
| SCHEMBL24702141 | 0.74 | ALDH1A1 (0.53) | ALDH1A1GAAMAPK1HSD17B10HRH3 | |
| SCHEMBL22197894 | 0.74 | ALDH1A1 (0.53) | ALDH1A1GAAMAPK1HSD17B10HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |