Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CFTR | P13569 | 2/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23976021 | 0.87 | PDE10A (0.56) | PDE10ATDP1CFTRMETAP2METAP1 | |
| SCHEMBL23975723 | 0.87 | PDE10A (0.46) | PDE10ATDP1POLBCFTRMETAP2 | |
| SCHEMBL23975705 | 0.86 | PDE10A (0.49) | PDE10ATDP1CFTRMETAP2METAP1 | |
| SCHEMBL30225178 | 0.86 | PDE10A (0.49) | PDE10ATDP1CFTRMETAP2METAP1 | |
| SCHEMBL26228677 | 0.86 | PDE10A (0.47) | PDE10AMAPTHTTTDP1POLB | |
| SCHEMBL23976223 | 0.86 | HDAC1 (0.37) | PDE10AMAPTHTTPOLBHDAC1 | |
| Hydrochloric Acid SCHEMBL30225193 | 0.85 | PDE10A (0.49) | PDE10ATDP1CFTRMETAP2METAP1 | |
| SCHEMBL30225284 | 0.85 | PDE10A (0.47) | PDE10ATDP1POLBCFTRMETAP2 | |
| SCHEMBL30225169 | 0.85 | NPC1 (0.37) | PDE10AMAPTHTTTDP1POLB | |
| SCHEMBL23976687 | 0.85 | NPC1 (0.37) | PDE10AMAPTHTTTDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |