Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23976687 | 0.90 | NPC1 (0.37) | HDAC1HDAC8HDAC6PDE10AMAPT | |
| SCHEMBL30225169 | 0.90 | NPC1 (0.37) | HDAC1HDAC8HDAC6PDE10AMAPT | |
| SCHEMBL23976647 | 0.88 | GAA (0.41) | HDAC1HDAC8HDAC6PDE10AMAPT | |
| SCHEMBL23976238 | 0.87 | SPR (0.40) | HDAC1HDAC8HDAC6PDE10AMAPT | |
| SCHEMBL30225199 | 0.87 | SPR (0.40) | HDAC1HDAC8HDAC6PDE10AMAPT | |
| SCHEMBL23976102 | 0.87 | SPR (0.38) | HDAC1HDAC8HDAC6PDE10AMAPT | |
| SCHEMBL23975786 | 0.86 | PDE10A (0.46) | HDAC1HDAC8HDAC6PDE10AMAPT | |
| SCHEMBL23975788 | 0.86 | KMT2A (0.45) | MEN1ALDH1A1KMT2APOLB | |
| SCHEMBL23975765 | 0.86 | GAA (0.41) | HDAC1HDAC8HDAC6PDE10AMAPT | |
| SCHEMBL23976220 | 0.85 | HDAC1 (0.35) | HDAC1HDAC8HDAC6PDE10AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |