Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23975627 | 0.81 | ALDH1A1 (0.54) | ALDH1A1EPHX2MAPK1L3MBTL1LMNA | |
| SCHEMBL24383312 | 0.79 | MAPT (0.64) | ALDH1A1EPHX2MAPK1L3MBTL1LMNA | |
| SCHEMBL24606366 | 0.79 | MAPT (0.64) | ALDH1A1EPHX2MAPK1L3MBTL1LMNA | |
| SCHEMBL24383487 | 0.79 | MAPT (0.64) | ALDH1A1EPHX2MAPK1L3MBTL1LMNA | |
| SCHEMBL23946128 | 0.79 | MAPT (0.64) | ALDH1A1EPHX2MAPK1L3MBTL1LMNA | |
| SCHEMBL24383446 | 0.79 | MAPT (0.64) | ALDH1A1EPHX2MAPK1L3MBTL1LMNA | |
| SCHEMBL23946129 | 0.79 | MAPT (0.64) | ALDH1A1EPHX2MAPK1L3MBTL1LMNA | |
| SCHEMBL24202656 | 0.79 | MAPT (0.64) | ALDH1A1EPHX2MAPK1L3MBTL1LMNA | |
| SCHEMBL25123271 | 0.79 | MAPT (0.64) | ALDH1A1EPHX2MAPK1L3MBTL1LMNA | |
| SCHEMBL24511381 | 0.79 | MAPT (0.64) | ALDH1A1EPHX2MAPK1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |