Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.30 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.30 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23976208 | 1.00 | ACSS2 (0.32) | ACSS2HDAC1HDAC8HDAC6CNR1 | |
| SCHEMBL23976053 | 0.93 | ANO1 (0.33) | ACSS2HDAC1HDAC8HDAC6CNR1 | |
| SCHEMBL23987006 | 0.93 | ANO1 (0.33) | ACSS2HDAC1HDAC8HDAC6CNR1 | |
| SCHEMBL23975839 | 0.90 | CNR1 (0.35) | HDAC1HDAC8HDAC6CNR1ACVR1 | |
| SCHEMBL23976487 | 0.90 | CNR1 (0.35) | HDAC1HDAC8HDAC6CNR1ACVR1 | |
| SCHEMBL30118827 | 0.90 | CNR1 (0.35) | HDAC1HDAC8HDAC6CNR1ACVR1 | |
| SCHEMBL23976868 | 0.90 | CNR1 (0.35) | HDAC1HDAC8HDAC6CNR1ACVR1 | |
| SCHEMBL23975841 | 0.90 | CNR1 (0.35) | HDAC1HDAC8HDAC6CNR1ACVR1 | |
| SCHEMBL23976491 | 0.90 | CNR1 (0.35) | HDAC1HDAC8HDAC6CNR1ACVR1 | |
| SCHEMBL30118731 | 0.90 | CNR1 (0.35) | HDAC1HDAC8HDAC6CNR1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |