Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 8/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | GCK | P35557 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23976219 | 1.00 | SYK (0.33) | SYKCACNA1HSPRACACBBRAF | |
| SCHEMBL23975672 | 0.89 | SYK (0.38) | SYK | |
| SCHEMBL30118646 | 0.87 | SYK (0.35) | SYKSPRACACBLNPEPGCK | |
| SCHEMBL30118726 | 0.87 | SYK (0.35) | SYKSPRACACBLNPEPGCK | |
| SCHEMBL23976179 | 0.87 | SYK (0.35) | SYKSPRACACBLNPEPGCK | |
| SCHEMBL23976471 | 0.87 | SYK (0.35) | SYKSPRACACBLNPEPGCK | |
| SCHEMBL23976645 | 0.87 | SYK (0.35) | SYKSPRACACBLNPEPGCK | |
| SCHEMBL23976799 | 0.87 | HDAC1 (0.35) | SYKCACNA1HSPR | |
| SCHEMBL30118813 | 0.87 | HDAC1 (0.35) | SYKCACNA1HSPR | |
| SCHEMBL23976813 | 0.84 | SYK (0.34) | SYKACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |