Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | PER2 | O15055 | 1/20 | 0.30 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.30 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17308201 | 1.00 | LTA4H (0.34) | LTA4HGRIN1GRIN2BBACE1GRM2 | |
| SCHEMBL15806912 | 0.88 | KCNH2 (0.34) | LTA4HKCNH2 | |
| SCHEMBL22725369 | 0.82 | PIK3CD (0.42) | LTA4H | |
| SCHEMBL14706858 | 0.82 | PIK3CD (0.42) | LTA4H | |
| SCHEMBL16803019 | 0.82 | PIK3CD (0.42) | LTA4H | |
| SCHEMBL17306143 | 0.81 | HRH3 (0.31) | — | |
| SCHEMBL24702297 | 0.80 | — | — | |
| SCHEMBL23206109 | 0.79 | LTA4H (0.33) | LTA4H | |
| SCHEMBL19617151 | 0.79 | LTA4H (0.33) | LTA4HPER2CRY1CRY2 | |
| SCHEMBL23158260 | 0.79 | LTA4H (0.33) | LTA4HBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |