Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MDM4 | O15151 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23975792 | 0.79 | TSHR (0.47) | CTSBTSHRSMN1; SMN2HTTCA1 | |
| SCHEMBL5987241 | 0.76 | CTSD (0.51) | BACE1CTSDMRGPRX4HDAC4HDAC8 | |
| SCHEMBL14001984 | 0.75 | CTSD (0.40) | BACE1CTSDMRGPRX4HDAC4HDAC8 | |
| SCHEMBL14200520 | 0.75 | CTSD (0.43) | BACE1CTSDMRGPRX4HDAC4HDAC8 | |
| SCHEMBL26726801 | 0.73 | MRGPRX4 (0.46) | BACE1CTSDMRGPRX4BCHEKDM4E | |
| SCHEMBL26723842 | 0.73 | MRGPRX4 (0.43) | BACE1CTSDMRGPRX4HDAC4HDAC8 | |
| SCHEMBL11509118 | 0.73 | MRGPRX4 (0.41) | BACE1CTSDMRGPRX4HDAC4HDAC8 | |
| SCHEMBL10154614 | 0.73 | KDM4E (0.41) | BACE1CTSDMRGPRX4HDAC4HDAC8 | |
| SCHEMBL10121249 | 0.71 | TACR1 (0.43) | BACE1CTSDMRGPRX4HDAC4HDAC8 | |
| SCHEMBL16919633 | 0.70 | HDAC4 (0.41) | BACE1CTSDMRGPRX4HDAC4HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |