Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | PAOX | Q6QHF9 | 4/20 | 0.39 |
| ▸ | SAT1 | P21673 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21370666 | 1.00 | CYP2C19 (0.50) | CYP2C19CYP1A2KDM1AMEN1GLA | |
| SCHEMBL24289039 | 0.98 | CYP2C19 (0.52) | CYP2C19CYP1A2KDM1AMEN1GLA | |
| SCHEMBL8675626 | 0.91 | — | — | |
| SCHEMBL18681683 | 0.84 | PAOX (0.50) | CYP2C19CYP1A2TSHRPAOXALDH1A1 | |
| SCHEMBL24040956 | 0.84 | ALDH1A1 (0.56) | TSHRPAOXALDH1A1 | |
| SCHEMBL22735242 | 0.84 | ALDH1A1 (0.56) | TSHRPAOXALDH1A1 | |
| SCHEMBL20960756 | 0.84 | PAOX (0.50) | CYP2C19CYP1A2TSHRPAOXALDH1A1 | |
| SCHEMBL20648073 | 0.84 | ALDH1A1 (0.56) | TSHRPAOXALDH1A1 | |
| SCHEMBL25714111 | 0.83 | CYP2C19 (0.46) | CYP2C19CYP1A2KDM1AMEN1GLA | |
| SCHEMBL25978589 | 0.82 | PAOX (0.52) | CYP2C19CYP1A2MEN1GLAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |